DPI: A Potential Drug Target for DNA Replication and Repair (P17651)

Target Name: DNA polymerase delta

NCBI ID: P17651

DNA polymerase delta

Other Name(s): None

DPI: A Potential Drug Target for DNA Replication and Repair

DNA polymerase delta (DPI) is a protein that plays a crucial role in DNA replication and repair in all living organisms. It is one of the four DNA polymerases that exist in the cell, and it is responsible for copying the double-stranded DNA template that is passed on to the daughter cell during cell division.

DPI is a small molecule that is composed of 126 amino acids. It has a molecular weight of 19.9 kDa and a pI (pH) of 6.5. DPI is widely expressed in all living organisms, including bacteria, archaea, and eukaryotes. It is also highly conserved, with only minor differences in its sequence among different organisms.

DPI is involved in a variety of cellular processes, including DNA replication, repair, and cell division. In DNA replication, DPI helps to synthesize the new double-stranded DNA template that is passed on to the daughter cell. It is also involved in repairing damaged DNA, as well as in regulating the timing of DNA replication.

DPI is a potential drug target for several reasons. Firstly, DPI is involved in cell division, which is a critical process for the survival and growth of all living organisms. As such, any drug that can inhibit DNA replication or repair may have broad implications for the health and survival of cells. Secondly, DPI is a small molecule that is relatively easy to manipulate, which makes it an attractive target for drug development. Finally, DPI is well-validated as a drug target, with several studies having identified potential binding sites on DPI.

DPI has also been identified as a potential biomarker for several diseases. For example, DPI has been shown to be downregulated in cancer cells, which may make it an attractive target for cancer therapies. In addition, DPI has been associated with a number of diseases, including neurodegenerative diseases, where DPI has been shown to be involved in the repair of damaged DNA.

In conclusion, DNA polymerase delta (DPI) is a protein that plays a critical role in DNA replication and repair in all living organisms. It is a small molecule that is well- conserved and widely expressed in all organisms. DPI is involved in a variety of cellular processes, including DNA replication, repair, and cell division, and is therefore an attractive target for drug development. Additionally, DPI has been identified as a potential biomarker for several diseases and is downregulated in cancer cells. Further research is needed to fully understand the role of DPI in cellular processes and its potential as a drug target or biomarker.

Protein Name: DNA Polymerase Delta

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•   general information;
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•   expression level;
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